Sam: Let me try.
Dean: I got it.
.. picking one randomly that I will never forget, in the pilot episode, where the brothers are in the library, looking at the monitor and studying their case of the woman in white, that was actually the very first day of production on supernatural […] I’ll just never forget it, ‘cause that was day one and he and I were already having a brother-like scene where I think you reach for the keyboard and I slap your hand away. That was instant and I knew then, that we had something that was .. that had potential. That we had a rapport that could go a long way with the show.
Jensen Ackles on the scene he’ll never forget - jibcon 2012 [vid]